ChR2, alone or combined with the other photostimulation techniques will be a minimally invasive technique, genetically targeted, and it will have temporally precise control of electrical activity of neurons. In oocytes of Xenopus laevis and mammalian cells, ChR2 is a
directly light-switched cation-selective ion channel and Petreanu et al. mapped the projections of pyramidal neurons in the barrel cortex using this method. Also, Arenkiel et al used this on mitral cells with the Thy1 promoter.
It is possible that the "classic" experiments to be reevaluated (where is possible) with this new method? Is this a new road in mental disorders research or a new way for the study of degenerative diseases of the brain? It is possible to evaluate in the future witch neuronal population is relevant to a behavior, witch population has a modulatory role in a behavior and witch population of neurons is dispensable? Hmm....
articles on this subject here
another article here
more about the subject here
and you can find more from here
and more links here
and here too.
neuroscience bucharest blog team